Holmes, 39, entered a federal women’s prison camp located in Bryan, Texas – where the federal judge who sentenced Holmes in November recommended she be incarcerated.

As she begins her sentence, Holmes is leaving behind two young children – a son born in July 2021 a few weeks before the start of her trial and a three-month old daughter who was conceived after a jury convicted her on four felony counts of fraud and conspiracy in January 2022.

Holmes was free on bail up until Tuesday, most recently living in the San Diego area with the children’s father, William “Billy” Evans. The couple met in 2017 around the same time Holmes was under investigation for the collapse of Theranos, a startup she founded after dropping out of Stanford University when she was just 19.

While she was building up Theranos, Holmes grew closer to Ramesh, “Sunny” Balwani, who would become her romantic partner as well as an investor and fellow executive in the Palo Alto, California, company.

Together, Holmes and Balwani promised Theranos would revolutionise health care with a technology that could quickly scan for diseases and other problems with a few drops of blood taken with a finger prick.

The hype surrounding that purported breakthrough helped Theranos raise nearly $US1 billion from enthralled investors, assemble an influential board of directors that include former presidential cabinet members George Shultz, Henry Kissinger and James Mattis and turned Holmes into a Silicon Valley sensation with a fortune valued at $US4.5 billion on paper in 2014.

But it all blew up after serious dangerous flaws in Theranos’ technology were exposed in a series of explosive articles in The Wall Street Journal that Holmes and Balwani tried to thwart.

Holmes and Balwani, who had been secretly living together while running Theranos, broke up after the Journal’s revelations and the company collapsed.

In 2018, the US Justice Department charged both with a litany of white-collar crimes in a case aimed at putting a stop to the Silicon Valley practice of overselling the capabilities of a still-developing technology – a technique that became known as “fake it ’til you make it.”

Holmes admitted making mistakes at Theranos, but steadfastly denied committing crimes during seven often-fascinating days of testimony on the witness stand during her trial.

Balwani, 57, was convicted on 12 counts of fraud and conspiracy in a trial that began two months after Holmes’ ended. He is currently serving a nearly 13-year sentence in a southern California prison.